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Cytotoxicity Testing


Cytotoxicity testing can be useful as a screening tool for pharmaceuticals before more extensive toxicological testing is performed. Additionally, cytotoxicity testing can be used for quality control purposes for lot release testing of raw materials or of manufactured drug products.

Cytotoxicity tests are designed to determine the toxicity to cells of compounds either qualitatively or quantitatively. Qualitative cytotoxicity tests offered by Pacific BioLabs are the MEM Elution Test, the Direct Contact Test, and the Indirect Contact Agar Diffusion Test. In addition, Pacific BioLabs offers a very sensitive quantitative cytotoxicity test, the MTT Assay. Guidelines for cytotoxicity testing are based on ANSI/AAMI/ISO 10993-5 and USP <87> and <88>.

To learn more about the different types of cytotoxicity tests, visit our Learning Center section on Cytotoxicity.

Available Cytotoxicity Tests

  • Agarose Overlay
  • MEM Elution
  • Direct Contact Cytotoxicity
  • Indirect Contact Agar Diffusion Test
  • MTT Assay (quantitative)


Intertek Logo PBL is FDA registered and ISO 9001:2008 and ISO 13485:2003 certified by Intertek. AAALAC Logo Our animal science operations are accredited by AAALAC.

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