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• ADME/PK (Absorption, Distribution, Metabolism, and Excretion/Pharmacokinetic)
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    Pharmacokinetic or ADME (Absorption/Distribution/Metabolism/ Excretion) studies provide useful feedback for formulation scientists. PK studies yield parameters such as AUC (area under the curve), Cmax (maximum concentration of the drug in blood), and Tmax (time at which Cmax is reached). Later on, this data from animal PK studies is compared to data from early stage clinical trials to check the predictive power of animal models.

    Form more information on drug development process click here.

• LOT (Lead Optimization Toxicology)
• Safety and Efficacy
• MTD (Maximum Tolerated Dose)

Download printable version of our booklet Preclinical Toxicology - Points to Consider in Program Design (PDF).